The use of TB iELISA test kits during eradication efforts is often misconstrued, and false expectations often prevent the proper use of this technology. Answering the question: “Which animal is positive?” often becomes sidelined. When using an iELISA test, high-positive animals will have obvious lesions and are often anergic. Medium-positive animals will have some lesions, and animals presenting a low-positive signal will have only antibodies (with or without lesions). We recommend using the iELISA test frequently (because of its affordable price) to find anergic animals and move them out of the herd. High-positive animals are often anergic to a skin test, and low-positive animals are easily detected using a skin test. Between these two technologies, the right pool of animals will be detected and removed. However, tests can only support important changes in the management system that actually prevent transmission and ultimately lead to the eradication of the disease.